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(2016) 353:i1585

Furthermore, Slomiany et al

Clinically important weight reduction requires a combination of a reduced-calorie diet and patient-centered physical-activity interventions, which may be challenging to adhere to but have been shown to improve patient-reported outcomes related to pain

Perform a patch test before first use to check skin sensitivity

Additionally, most of the articles assessed disagreed on many points related to study results which led to differences in interpretations of recommendations

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