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This exercise-responsive pattern led researchers to propose MOTS-c as a mitokine, a signaling molecule released by the mitochondria during physical exertion that mediates some of the systemic benefits of exercise

It is believed to influence levels of dopamine, norepinephrine, and serotonin in the brain key neurotransmitters involved in satiety, mood, and metabolism

Combined use of both compounds is entirely unstudied in humans and carries unpredictable metabolic and cardiovascular risks

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