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In one study evaluating the prevalence of vitamin C deficiency in IBD patients, 21.6% of patients in the study had a vitamin C deficiency (24.4% of Crohns disease patients and 16% of ulcerative colitis patients)

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With that proof of concept in hand, we then investigated the possibility of combining the peptide/oligourea hybrid approach with the protraction strategy, which consists of functionalizing a peptide with a fatty acid chain to promote its binding to albumin and prolong its in vivo half-life

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