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While we cannot reproduce clinical photographs from the cited studies without permission, we can describe what the published cases document: Patil and Mitra (2026) describe tongue hyperpigmentation in the context of Addison's disease - typically presenting as diffuse darkening of the tongue surface, often alongside pigmentation of other mucosal surfaces and skin creases

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The 2016 Draelos study in Journal of Drugs in Dermatology compared a crosslinked HA serum with recombinant EGF against a fibroblast-conditioned media serum and documented meaningful improvements in skin appearance and texture [31]

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