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The point that should be considered about non-selective TKIs is that the anti-tumor function of these inhibitors might be higher than that of selective c-Met inhibitors due to inhibition of multiple kinases

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Unlike plasticity in a healthy brain, compensatory plasticity in a damaged brain begins in critical situations related to inflammation, edema, apoptosis, degeneration of nerve fibers, and metabolic disorders [8]

214 Therefore, to achieve large-scale clinical application, NADs must ensure easy production, quality control, and transportation