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Trial REDEFINE 11 (ongoing) Phase 3 Duration Longer duration Population (N) Adults with BMI 30 Key Result Long-term efficacy and maintenance readout pending

GLP-1 receptor activation suppresses IL-1 beta through multiple pathways, including direct NF-kB inhibition and reduced inflammasome activation

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doi: 10.1093/gerona/58.11.b970

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