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rosea demonstrates neurotrophic capabilities by enhancing the expression of BDNF and facilitating the activation of downstream TrkBCREB signaling pathways, which are essential for synaptic plasticity, neuronal survival, and neurogenesis (56)

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The reduction of the mitochondrial [NAD + ]/[NADH] during DR (Hagopian et al., 2003) decreased SIRT4 activity as well as its ADP-ribosylation of GLUD1, preserving GLUD1 activity (Pannek et al., 2017)

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