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PMID: 39037153 Hum Mutat2026 Mar 23;2026(1):7170837

It can either involve oral supplements or injections

Intramuscular vitamin D injections are usually administered into the deltoid muscle of the arm or the gluteal muscle

Evaluation of Pharmacodynamic Response Improvement due to Increased Drug Delivery The final aim of the transporter-mediated drug delivery approach is to increase the concentration of the delivered drug at the target site in the brain, resulting in higher pharmacological response

In accordance with this concept, a study investigating age-related changes in RAR and RXR subtypes gene expression and tissue transglutaminase activity in human peripheral blood mononuclear cells (PBMCs) before and after supplementing 13- cis -retinoic acid found that the expression of RXR- in healthy elderly men (65.4 3.8 y/o) was significantly reduced compared to younger men (26.1 4.1 y/o) [116]