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Here's What to Actually Expect So you've finally got your prescription for a GLP-1 Ozempic, Wegovy, Zepbound, or Mounjaro and your feelings are somewhere between excited and terrified

Biological plausibility suggests BDNF receptor desensitization could occur with chronic stimulation a 2025 rodent study found that BDNF-stimulating compounds led to receptor downregulation within 16 weeks, requiring higher doses to maintain effect

ARIA risk increases with drug dose, thus raising the potential for a tradeoff between safety and efficacy that needs to be considered in development of dosing regimens (Boxer and Sperling, 2023)

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Right rip disarticulation and inguinal lymphadenectomy were performed uneventfully