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Drugs that target glucagon-like peptide 1 (GLP-1) have gained lots of attention for their potential health benefits

This suggests that some therapeutic benefits of canagliflozin could result from the activation of AMPK, rather than inhibition of SGLT2 ( DPP-4 inhibitors These compounds, by preventing deactivation by dipeptidyl peptidase-4 (DPP4) inhibitors, improve the concentration of endogenous incretins (Vangoitsenhoven et al., 2012)

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However, GLP-1s also offer well-established research with fewer gastrointestinal side effects

A study found that slower gastric emptying was a key factor in the increased satiety and reduced hunger experienced by participants taking GLP-1 agonists