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Some have reported kidney-related issues due to severe dehydration resulting from prolonged vomiting or diarrhea

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The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance

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This anxiogenic role of GLP-1 is likely tightly linked with the role brain GLP-1Rs play in interoceptive stress responses (108, 111)