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Prescription drug prices, including Vitamin B12 Injection, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations

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Mercadante S et al 2009: High-dose furosemide and small-volume hypertonic saline solution infusion for the treatment of leg edema in advanced cancer patients This is a prospective cohort study in Italy describing 24 patients with advanced malignancy and peripheral edema refractory to conventional diuretic therapy