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Thiamin-responsive pyruvate dehydrogenase complex (PDHC) deficiency Mutations in PDHC prevent the efficient oxidation of carbohydrates in affected individuals

Key rules: Common mistake: Taking these at random times throughout the day

Results are stratified by the decadal age range in which treatment begins and by either peoples 10-year risk category for developing diabetes (panel a) or peoples baseline BMI range (panel b)

No large human randomized controlled trial exists for either compound in any musculoskeletal use

In a phase 2 trial, once-monthly dosing produced significant weight loss at 52 weeks: 12.3% to 16.2% in patients with obesity without diabetes ( vs 2.5% with placebo), and 8.4% to -12.3% in those with obesity and type 2 diabetes ( vs 1.7% with placebo)