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Hsu et al used the TriNetX platform to study the association between semaglutide use and the incidence of NAION and found that it was associated with an increased risk in patients with diabetes at the 2-, 3-, and 4-year timepoints but not within 1 year of GLP-1 RA initiation

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It is also expressed at lower levels in the gut, kidneys, liver, heart, muscle and the PNS (6)