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Ultimately, this review proposes that PEM may arise from a complex interplay among mitochondrial dysfunction, immune activation, and neuroinflammation, which together form a self-perpetuating loop of energy exhaustion - inflammation amplification, potentially contributing to the chronic and multi-system nature of PEM symptoms

Cognitive impairment in the first year after breast cancer diagnosis: a prospective cohort study

Adams JD Jr, Klaidman LK, Odunze IN, Shen HC, Miller CA (1991)

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