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GLP-1 receptor agonists are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Additional precautions include not rubbing the treated area to prevent the Botox from spreading to unintended areas and avoiding sleeping on their backs the first night after treatment

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For the systemic injury and recovery uses that TB-500 is actually marketed for, the supporting data are animal models and in-vitro work on thymosin beta-4 and its actin-binding domain