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Flint A, Raben A, Rehfeld JF, Holst JJ, Astrup A
This vastly exceeded the 14.9% average weight loss with semaglutide 2.4 mg weekly in the STEP-1 trial
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Tirzepatide, the active ingredient in Mounjaro and Zepbound, is a 39-amino acid dual agonist targeting both GLP-1 and GIP receptors, also incorporating a fatty acid modification for half-life extension, and is the most commercially significant synthetic peptide ever produced at scale
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