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Constipation: Counterintuitively, also common, especially with higher doses of tirzepatide and retatrutide

However, some tirzepatide users report joint pain as a side effect, possibly related to rapid body composition changes or dehydration

How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test examines key variants in GLP1R, GIPR, FTO, and MC4R pathways that may influence how your body metabolizes tirzepatide and responds to GLP-1 receptor agonism

Gentle Movement: A short walk can help stimulate digestion if you are feeling bloated or constipated

You may need to take the medication for several weeks or months before you start to see significant weight loss