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Exposure to phentermine or GLP-1 medications in the first trimester yielded similar results to exposure in the 90 days prior to pregnancy, as shown in Figure 3

The detailed search strategies are comprehensively outlined in Supplementary Table 1

We first extracted six types of Catalogue of Somatic Mutations in Cancer (COSMIC) single nucleotide variant signatures associated with dMMR (Sig dMMR ), and calculated the contribution rate of Sig dMMR among the total somatic mutations in each sample

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One of the most surprising findings, according to Gler, was how these drugs [activated] the emotion center and [engaged] the reward mechanisms in the brain. When the researchers gave mice a standard diet, which Gler described as the equivalent of salads for humans, the drugs had no effect