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KLOW's metabolic effects
Clinical trials have shown that adding a GLP-1 drug to established metformin therapy produces greater weight loss and HbA1c reduction than either drug alone
Mol Metab (2021) 51:101241
These effects were more pronounced in patients with baseline eGFR below 60 mL/min/1.73 m 2
Indeed, several molecules have been implicated in the same direction regulation of APOC3 and APOA5 expression, including upregulation with hepatocyte nuclear factor 4- (HNF4-) [15, 16] and glucose [17, 18], and downregulation with AMP-activated protein kinase [15, 19], insulin [20,21,22] and tumor necrosis factor- (TNF-) [23, 24]
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