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McDaid, A novel indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

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Weight Fluctuations: Some individuals have reported unintended weight gain or loss, though evidence on this is limited

After a mean of 9.3 years, the recurrence of postoperative curvature had increased from 0% after a mean of 38 months (1873 months) to 23.7%, post-op erectile dysfunction increased from 3.0% to 39.5%, penile shortening from 0.0% to 65.8%, and impairment of penile sensitivity from 3% to 31.4%

The appetite decrease is of course part of the intended mechanism, but it can become excessive during aggressive titration, leading to inadequate caloric and protein intake