Nanoparticle systems, including liposomes, polymeric nanoparticles, and solid lipid nanoparticles, could improve peptide stability but suffered from batch-to-batch variability, limited scalability, and absorption efficiencies that rarely exceeded 5% in human studies
This means that a peptide can have extraordinary neurotrophic potential in a cell culture dish but be completely ineffective in a living organism if it cannot physically reach the brain
42 Managing The Complexities of Glucagon-Like Peptide-1 Receptor Agonist Drug Development Current and future development of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or simply GLP-1s, involves complexities not only in formulation but in all areas of early-phase drug development
10.1186/s12967-022-03631-0 113 LalR.DharavathR
A retrospective cohort study for acute exacerbation patients with non-IPF and IPF showed overall survival rates of 67% at 30 days, 43% at 60 days, and 40% at 90 days 3