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From Obesity to Metabolic Health: Why Retatrutide Is a Game-Changer Abstract Obesity and type 2 diabetes have become global health crises, fueling complications such as cardiovascular disease, fatty liver disease, and metabolic syndrome

Interestingly, LDLR expression increased following inhibition of SREBP-2 or AMPK by siRNA, and also following treatment with thapsigargin, an endoplasmic reticulum stress inducer activating SREBP-2, or AICAR, an AMPK agonist

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