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Bottled, distilled, and tap water are not sterile injectable solvents

After quality control, we identified 47,413 cases of CAD (31,127 in men, 16,286 in women), 7961 cases of ischemic stroke (4915 in men, 3046 in women), 12,926 cases of heart failure (8456 in men, 4470 in women), and 18,382 cases of AF (12,260 in men, 6122 in women)

This includes things like headaches or mild fatigue

Yes, and even particularly interesting

Phosphodiesterase-5 inhibitors such as sildenafil are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrates and should be used cautiously in certain cardiovascular conditions