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This immune activation leads to a persistent inflammatory state within the colonic mucosa, contributing to the chronic nature of UC

The CagA protein increases iron uptake through TF endocytosis and decreases cytoplasmic labile iron pool while increasing lysosomal iron through enhanced expression of H-ferritin in H

Similarly, oxaliplatin prompts the senescence in the same mechanism as cisplatin, of cancer cells extracted from rats with sizable tumors in the colon [45, 77]

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The extent of the increase, which seems to be genotype dependent, was about 2-fold at 9 C after 4 months or up to 1.8-fold at 4 C after 7 months 151,152