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Three derivatives of the D-Nle-X-Ile-(6)amino- hexanoic amide, where X is: Cys, Trp, or Met were examined to determine whether the percent of inhibition of dimerization and the binding affinity for each compound for HGF could be correlated to in vitro cellular activity, namely inhibition of MDCK cell scattering

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showed that iron overload could reduce peripheral T-cells, decrease Th1/Th2 as well as Tc1/Tc2 ratio and increase CD4/CD8 ratio as well as the fraction of regulatory T-cells by inducing ROS-mediated oxidative stress and apoptosis of T-lymphocytes

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