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Lack of approval reflects insufficient human clinical trial data and incomplete evaluation of risks, dosing, and long-term effects

Other non-insulin mechanisms of hepatic GH resistance in anorexia nervosa have also been described, including fibroblast growth factor-21, sirtuin 1, triiodothyronine, leptin and testosterone (63)

Additionally, if bacterial dysbiosis is present alongside Candida, treating only the fungal component won't resolve the full picture