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J Clin Lab Anal 30(5):506509 Liang C et al (2015) A subchronic oral toxicity study on Pyrroloquinoline quinone (PQQ) disodium salt in rats

However, the magnitude of some of these observational estimates (for example, relative reductions in cardiovascular or all-cause mortality exceeding 50%) is considerably larger than would be predicted from the randomized effect sizes of either class and is almost certainly inflated by residual and time-related confounding, including healthy-adherer and prevalent-user biases

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Elife 2018, 7, e37268 10.7554/eLife.37268

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