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The decrease in SF3B1 phosphorylation observed after longer inhibition ( 1 h) can be attributed to roles of these kinases in transcription, a process upstream of splicing 8,20,72 , and, in the case of CDK7 to its recently described role in CDK11 activation 75,82,83

10.1093/chromsci/bmy110 25 DallakM.DawoodA

Biomedicines 12 (3), 620

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Bioinformatics analysis The total protein contents of untreated Raji cells, Raji cells treated with TPA for 24 h and Raji cells treated with TPA and 200 ng/ml TNF- were analysed by quantitative proteomics