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For instance, H7 of GLP-1 forms hydrogen and hydrophobic interactions with TM3 and TM5 residues like Y 241 , I 309 , R 310 , and I 313 , whereas A8 forms hydrophobic interactions with L 384 and L 388 of TM7

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Increase in number and activity of macrophages is accompanied by release of more cytokines and other immune mediators, such as NO