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Each compound acts on distinct biological pathwaysangiogenesis, inflammatory modulation, neuroprotection, or actin regulation

The prevailing model for NRF2-dependent target gene expression involves the binding of NRF2 to ARE sequences within proximal promoters of specific target genes (Tonelli et al, 2018)

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Indeed, EIC rats show a massive oxidative stress and lipid peroxidation as evidenced by a significant drop in the hepatic GSH content and a subsequent increase in the hepatic thiobarbituric acid reactive substances (TBARS) levels (Chen et al., 2019)