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[103] Criticisms of semaglutide center on uncertainties in long-term safety, as pivotal trials extend only up to two years, leaving gaps in data for lifelong use amid rising off-label applications

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Specifically, liraglutide reduced phylotypes associated with obesity (e.g., Roseburia, Erysipelotrichaceae Incertae Sedis, Marvinbryantia, Parabacteroides ) and enriched genera related to thinness (e.g