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74 This may partly explain the ability of GLP-1RAs to reduce MACE incidence, which has been demonstrated in research

However, semaglutide has more clinical trial data and has shown benefits in treating various conditions like heart disease, kidney disease, and liver disease, sometimes independently of its effects on weight or glucose

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While injectable semaglutide's delayed gastric emptying has not shown clinically meaningful effects on most oral medications, providers should monitor patients taking medications with narrow therapeutic windows

Trulicity may increase the risk of thyroid cancer