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Epub 2010 Sep 16

Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses ( 2.2.4 Endoplasmic reticulum stress Endoplasmic reticulum (ER) stress plays a central role in metabolic, vascular, and neuroinflammatory disorders

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