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10.1155/2021/8816041 [DOI] [PMC free article] [PubMed] [Google Scholar] 65.Caioni G, Viscido A, Angelo M, Panella G, Castelli V, Merola C, Frieri G, Latella G, Cimini A, Benedetti E

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however, 32% experienced adverse events, including liver dysfunction and one case of anaphylaxis

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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts