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Thus, metformin inhibits mitochondrial respiratory chain complex IV, indirectly inhibiting mGPDH activity [26]

Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, et al

The mechanism is mainly through stimulation of the nitric oxide system, with secondary effects on VEGFR-2 (which drives angiogenesis and explains the wound healing), the serotonin and dopamine systems, COX-2, and HO-1

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