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Dual versus monotherapy with SGLT2 inhibitor and GLP-1 receptor agonist: PRECIDENTD pragmatic randomized trial

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

Because that's exactly what your metabolism is supposed to do

You build up to it over weeks, allowing your body to adapt to the medication and minimizing gastrointestinal side effects

Dehydration can often lead to headaches, particularly when your appetite decreases