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This metabolic inflexibility in Insr P1195L/ + mice could be also due to compensatory increase in fat utilization in fat and skeletal muscle during dark phase caused by impaired glucose uptake in these tissues

The results were consistent: Trunk fat reduction: Tesamorelin-treated patients showed statistically significant reductions in trunk fat versus placebo at 26 weeks.[1] VAT reduction: Using cross-sectional CT imaging, tesamorelin produced approximately 1520% reductions in visceral adipose tissue compared to placebo.[1,2] Triglyceride improvement: Alongside fat reduction, tesamorelin improved triglyceride levels a key marker in metabolic syndrome.[2] Tesamorelin IGF-1 elevation: Treatment reliably elevated IGF-1 levels toward age-appropriate norms, confirming successful GH-axis stimulation.[1] These reductions occurred without dietary caloric restriction being mandated