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Limitations included the predominantly White and female participants, as well as normal baseline metabolic values, which may have attenuated the improvements

These properties make PT141 a welldefined reference peptide for studying melanocortin signalling under controlled laboratory conditions.\n\nIn biochemical and cellular research systems, PT141 acts as an agonist at the centrally expressed melanocortin receptors MC3R and MC4R, with comparatively higher potency at MC4R and substantially reduced activity at MC1R relative to Melanotan II

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Khara, J.S., Lim, F.K., Wang, Y., Ke, X.Y., Voo, Z.X., Yang, Y.Y., et al., Acta Biomater