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The adaptation period can last weeks to months, during which skin may look worse before improving

Cortisol inhibits the activities of 5- and 6-desaturases, reducing the synthesis of -3 long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA)

However, more extensive human trials are necessary to draw firm conclusions