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The mechanism-curious optimizer, the engineer who reads pharmacology papers for fun, may end up benefiting most from the biased-signaling story, not because they will take NNC5840 in 2027 but because the molecules that come out of that research program over the next decade are likely to be the ones that get the side-effect profile right for indefinite-duration use in metabolically healthy people

Rushing through the titration schedule is the number one cause of severe combined GI symptoms

some people do not fully adjust and may need to discuss their options with their prescriber

van den Bree MBM, Pickworth WB

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