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Patients at increased risk of gastrointestinal bleedingsuch as those aged over 65 years, with a history of peptic ulcer disease, or taking corticosteroids or selective serotonin reuptake inhibitors (SSRIs)may benefit from co-prescription of a proton pump inhibitor (PPI) for gastroprotection, as recommended by NICE guidance

While tirzepatide slows how quickly food leaves your stomach, it actually may increase intestinal transit time by altering the natural muscular contractions (motility) of your intestines

Rather than dosing early, discuss a dose increase with your provider

Limiting your intake of carbohydrates, lean protein, essential vitamins and minerals, and healthy fats (even if youre not consuming fewer calories) can also cause prolonged fatigue

Drink water, clear broths, diluted sports drinks, or oral rehydration solutions to replace fluid and electrolyte losses