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13 These findings are consistent with results from the SURPASS-1 trial, in which tirzepatide at all studied doses significantly improved HbA1c over 40 weeks without increasing hypoglycemia risk

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Another potential reason contributing to withdrawals was a perception of ineffective glycemic and body weight control achieved (including a suspicion to have been randomized to placebo), perhaps as a consequence of the progression of the type 2 diabetes mellitus disease process [176]

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