However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis
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But at the same time, research shows GLP-1s may improve wound healing, reduce psoriasis inflammation, and potentially help other skin conditions
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2013;305:E89-100
