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Typical descriptions of this symptom include a patient who goes to bed and awakens by severe pain in the big toe but may also be experienced in the heel, instep or ankle

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doi: 10.3389/fimmu.2025.1525623 Received 11 November 2024 Accepted 19 February 2025 Published 11 March 2025 Volume 16 - 2025 Edited by James Cheng-Chung Wei, Chung Shan Medical University Hospital, Taiwan Reviewed by Venkateswarlu Kanamarlapudi, Swansea University Medical School, United Kingdom Ching-Hua Huang, Chung Shan Medical University Hospital, Taiwan Updates Copyright 2025 Sun, Hao, Liu and Gao