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USA 102 , 90509055 (2005)

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310,311 HMGCR is an ER membraneanchored protein responsible for catalyzing the rate-limiting step of sterol biosynthesis, namely, the reduction of -hydroxy -methylglutaryl-CoA (HMG-CoA) to mevalonate, a key intermediate in the synthesis of cholesterol and nonsterol isoprenoids, such as geranylgeranyl pyrophosphate (GGpp)

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