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These agents may provide a distinctive solution to PCOS pathology by linking metabolic dysfunction with nociceptive sensitization

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Mechanisms hypothesised to underlie blood pressure reduction with tirzepatide include: Weight reduction : Loss of adipose tissue decreases sympathetic nervous system activity, reduces cardiac output, and improves insulin sensitivityall contributing to lower blood pressure Natriuresis : GLP-1 receptor activation may promote sodium excretion through renal effects, though direct evidence for tirzepatide is limited Improved endothelial function : Weight loss and metabolic improvements may enhance vascular health Reduced inflammation : Adipose tissue reduction decreases pro-inflammatory cytokines that may contribute to hypertension It is important to note that whilst the blood pressure reductions are consistent across trials, tirzepatide is not licensed as an antihypertensive agent

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In the past, this would include commonly recognized therapies like Ozempic (semaglutide), Trulicty (dulaglutide), and Victoza (liraglutide)

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Vitamin C cannot be produced in the body, it has to be taken externally

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