Age does not appear to meaningfully alter semaglutide pharmacokinetics, and no dose adjustments are recommended for elderly patients
Your prescribing Kaiser physician can request a direct conversation with the Kaiser pharmacy reviewer who denied the PA
She said she hoped the expanded approval would improve insurance coverage, particularly as generic weight-loss drug alternatives can carry heart risks, but noted that if insurance comes on board with this indication, she has no idea how manufacturing will ever catch up. But, Dushay added, this might also help prioritize use of [the drugs] among those with highest-risk obesity, those who also have cardiovascular disease
Recent data suggest potential benefits in heart failure with preserved ejection fraction (HFpEF) with obesity, but monitoring is important, particularly during initiation
Thus, it is extremely hard to guess how much weight loss someone would experience based on their dosing alone