oral tirzepatide studies TrimRX What is the pipeline for

Washout approach (more common): Administer final Wegovy dose Wait 7 to 10 days (approximately 1.5 half-lives) Start Zepbound 2.5 mg Rationale: minimizes overlapping GLP-1 receptor activation, reduces nausea risk Overlap approach (less common, used when continuous appetite suppression is critical): Administer final Wegovy dose Start Zepbound 2.5 mg 3 to 4 days later Rationale: prevents gap in therapeutic effect during washout Risk: higher nausea and GI side effect burden during overlap window Most providers use washout

29,30 Its also been shown to neutralize free radicals 31,32 and reduce inflammation

Anything beyond that needs stronger evidence

[22] Gastroparesis can result in a partially or completely paralyzed stomach and can cause nausea, vomiting, and stomach pain

Berger ML, Sox H, Willke Rea et al (2017) Good practices for real-world data studies of treatment and/or comparative effectiveness: recommendations from the joint ISPOR-ISPE Special Task Force on real-world evidence in health care decision making