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Despite most prokaryotes and animals possess enzymes that require B12 as cofactor, only some bacteria and archaea are able to synthesize B12 de novo 3

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Results showed Cerebrolysin was significantly more effective than placebo for cognitive function at 4 weeks (SMD -0.40, p=0.003), global clinical change at both 4 weeks (OR 3.32, p=0.02) and 6 months (OR 4.98, p=0.015), and combined global benefit (cognitive + clinical) at both timepoints

What is globally accepted for peptides in solution is that they are generally stable for 3 or more weeks at +4C and for 3-4 months at -20C

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